I moved to the Netherlands and joint the Organisation for the Prohibition of Chemical Weapons (OPCW) in September 2012. I will keep this site as a repository of earlier work and I am working on a version “2.0”. However Blum – Scientific Services as a commercial entity ceased operations.
Based on structural and mechanistic knowledge, mutants of the phosphotriesterase enzmye DFPase were created that reverse the enantioselectivity of the enzyme from the less toxic to the more toxic stereoisomer of G-type nerve agents. The mutants not only feature a reversed enantioselectivity but also increased enzymatic activity compared to the wildtype. The results are described in a new paper published in the Journal of the American Chemical Society (JACS).
Blum Scientific Services is active in research & development of new and environmentally benign ways to combat the effects of CBRN (chemical, biological, radiological and nuclear) threats. One of our core areas of interest is the decontamination and detoxification of chemical warfare agents with the help of enzymes.