Peer-reviewed articles

Clicking on the DOI link or the title image will take you to the respective journal page.

  • Adduct of the blistering warfare agent sesquimustard with human serum albumin and its mass spectrometric identification for biomedical verification of exposure.
    Blum MM, Richter A, Siegert M, Thiermann H, John H.
    Anal. Bioanal. Chem. 2020; 412:7723-7737.
    DOI: 10.1007/s00216-014-7706-y

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  • Advice on chemical weapons sample stability and storage provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons to increase investigative capabilities worldwide.
    Timperley CM, Forman JE, Abdollahi M, Al-Amri AS, Alonso IP, Baulig A, Borrett V, Cariño FA, Curty C, Berrutti DG, Kovarik Z, Martínez-Álvarez R, Mikulak R, Mourão NMF, Ponnadurai R, Neffe S, Raza SK, Rubaylo V, Takeuchi K, Tang C, Trifirò F, van Straten FM, Vanninen PS, Zaitsev V, Waqar F, Zina MS, Blum MM, Gregg H, Fischer E, Sun S, Yang P.
    Talanta. 2018;188:808-832.
    DOI: 10.1016/j.talanta.2018.04.022

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  • Sampling and analysis of organophosphorus nerve agents: analytical chemistry in international chemical disarmament.
    Fischer E, Blum MM, Alwan WS, Forman JE.
    Pure Appl. Chem. 2017; 89(2):249-258.
    DOI: 10.1515/pac-2016-0902

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  • Analytical chemistry and the Chemical Weapons Convention.
    Blum MM, Mamidanna RVSM.
    Anal. Bioanal. Chem. 2014; 406(21):5067-5069. 
    DOI: 10.1007/s00216-014-7931-4

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  • V-type nerve agents phosphonylate ubiquitin at biologically relevant lysine residues and induce intramolecular cyclization by an isopeptide bond.
    Schmidt C, Breyer F, Blum MM, Thiermann H, Worek F, John H.
    Anal. Bioanal. Chem. 2014; 406(21):5171-5185. 
    DOI: 10.1007/s00216-014-7706-y

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  • An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: phase behavior, structure, and enzyme activity.
    Stehle R, Schulreich C, Wellert S, Gäb J, Blum MM, Kehe K, Richardt A, Lapp A, Hellweg T.
    J Colloid Interface Sci. 2014; 413:127-132. 
    DOI: 10.1016/j.jcis.2013.09.027

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  • Historical perspective and modern applications of Attenuated Total Reflectance –
    Fourier Transform Infrared Spectroscopy (ATR-FTIR).

    Blum MM, John H.
    Drug Test. Anal. 2012; 4(3-4):292-308. 
    DOI: 10.1002/dta.374

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  • In vitro and in vivo efficacy of PEGylated Diisopropyl Fluorophosphatase (DFPase).
    Melzer M, Heidenreich A, Dorandeu F, Gäb J, Kehe K, Thiermann H, Letzel T, Blum MM.
    Drug Test. Anal. 2012; 4(3-4):262-270. 
    DOI: 10.1002/dta.363

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  • Review on UV-spectroscopic, chromatographic and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM).
    John H, Blum MM.
    Drug Test. Anal. 2012; 4(3-4):179-193. 
    DOI: 10.1002/dta.327

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  • The DFPase from Loligo Vulgaris in sugar surfactant based bicontinuous microemulsions.
    Wellert S, Tiersch B, Koetz J, Richardt A, Lapp A, Holderer O, Gäb J, Blum MM, Schulreich C, Stehle R, Hellweg T.
    Eur. Biophys. J. 2011; 40(6):761-774. 
    DOI: 10.1007/s00249-011-0689-0

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  • Formation of pyrophosphate-like adducts from nerve agents sarin, soman and cyclosarin in phosphate buffer:
    Implications for analytical and toxicological investigations.

    Gäb J, John H, Blum MM.
    Toxicol. Lett. 2011; 200(1):34-40. 
    DOI: 10.1016/j.toxlet.2010.10.011

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  • Neutron structure and mechanistic studies of diisopropyl fluorophosphatase (DFPase).
    Chen JC, Mustyakimov M, Schoenborn B, Langan P, Blum MM.
    Acta Crystallogr. Sect. D Biol. Crystallogr. 2010; 66(11):1131-1138. 
    DOI: 10.1107/S0907444910034013

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  • Structural characterization of the catalytic calcium binding site in diisopropyl fluorophosphatase (DFPase) and comparison with related beta-propeller enzymes.
    Blum MM, Chen JC.
    Chem. Biol. Interact. 2010; 187(1-3):373-379. 
    DOI: 10.1016/j.cbi.2010.02.043

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  • X-ray structure of perdeuterated diisopropyl fluorophosphatase (DFPase):
    Perdeuteration of proteins for neutron diffraction.

    Blum MM, Tomanicek S, John H, Hanson L, Rüterjans H, Schoenborn BP, Langan P, Chen JC.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010; 66(4):379-385.
    DOI: 10.1107/S1744309110004318

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  • Stable adducts of nerve agents sarin, soman and cyclosarin with TRIS, TES and related buffer compounds –
    Characterization by LC-ESI-MS/MS and NMR and implications for analytical chemistry.

    Gäb J, John H, Melzer M, Blum MM.
    J. Chromatogr. B 2010; 878(17-18):1382-1390.
    DOI': 10.1016/j.jchromb.2010.01.043

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  • Monitoring the hydrolysis of toxic organophosphonate nerve agents by diisopropyl fluorophosphatase (DFPase) in aqueous buffer and bicontinuous microemulsions with 1H-31P-HSQC NMR spectroscopy.
    Gäb J, Melzer M, Kehe K, Wellert S, Hellweg T, Blum MM.
    Anal. Bioanal. Chem. 2010;396(3):1213-1221.
    DOI: 10.1007/s00216-009-3299-2

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  • Reversed Enantioselectivity of Diisopropyl Fluorophosphatase Against Organophohpsorus Nerve Agents by Rational Design.
    Melzer M, Chen JC, Heidenreich A, Gäb J, Koller M, Kehe K, Blum MM.
    J. Am. Chem. Soc. 2009;131(47):17226-17232.
    DOI: 10.1021/ja905444g

    Highlighted in Nature Chemistry:
    Nature Chem. 2010;2(1):4-5.
    DOI: 10.1038/nchem.487

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  • Rapid determination of hydrogen positions and protonation states of diisopropyl fluorophosphatase by joint neutron and X-ray diffraction refinement.
    Blum MM, Mustyakimov M, Rüterjans H, Kehe K, Schoenborn BP, Langan P, Chen JC.
    Proc. Natl. Acad. Sci. U S A. 2009 Jan 20;106(3):713-8.
    DOI: 10.1073/pnas.0807842106

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  • Quantification of hydrolysis of toxic organophosphates and organophosphonates by diisopropyl fluorophosphatase from Loligo vulgaris by in situ Fourier transform infrared spectroscopy.
    Gäb J, Melzer M, Kehe K, Richardt A, Blum MM.
    Anal. Biochem. 2009; 385(2):187-193.
    DOI: 10.1016/j.ab.2008.11.012

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  • Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.
    Blum MM, Timperley CM, Williams GR, Thiermann H, Worek F.
    Biochemistry 2008; 47(18):5216-24.
    DOI: 10.1021/bi702222x

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  • Preliminary time-of-flight neutron diffraction study on diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris.
    Blum MM, Koglin A, Rüterjans H, Schoenborn B, Langan P, Chen JC.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2007; 63(1):42-5.
    DOI: 10.1107/S1744309106052924

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  • Binding of a designed substrate analogue to diisopropyl fluorophosphatase: implications for the phosphotriesterase mechanism.
    Blum MM, Löhr F, Richardt A, Rüterjans H, Chen JC.
    J. Am. Chem. Soc. 2006; 128(39):12750-7.
    DOI: 10.1021/ja061887n

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  • Was wissen Calamari über Sarin? Enzymatische Dekontamination von Nervenkampfstoffen
    Richardt A, Blum MM, Mitchell S.
    Chemie in unserer Zeit. 2006; 40(4):252-259.
    DOI: 10.1002/ciuz.200600364

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  • Conformational switches modulate protein interactions in peptide antibiotic synthetases.
    Koglin A, Mofid MR, Löhr F, Schäfer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dötsch V.
    Science. 2006; 312(5771):273-6.
    DOI: 10.1126/science.1122928

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