Peer-reviewed articles
Clicking on the DOI link or the title image will take you to the respective journal page.Backbone and side chain chemical shift assignment of diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris, an organophosphorus-degrading enzyme
Chen JC, Tonelli M, Anderson P, Michalczyk R, Blum MM, Williams RF
Biomol. NMR Assign. 2023, ePub ahead of print
DOI: 10.1007/s12104-023-10120-yActivation of the Human TRPA1 Channel by Different Alkylating Sulfur and Nitrogen Mustards and Structurally Related Chemotherapeutic Drugs
Müller-Dott K, Raßmuß SC, Blum MM, Thiermann H, John H, Steinritz D
Toxicol. Lett. 2023; 376:51-59.
DOI: 10.1016/j.toxlet.2023.01.007No chemical killer AI (yet)
Blum MM.
Nature Mach. Intell. 2022; 4:506-507.
DOI: 10.1038/s42256-022-00497-1Adduct of the blistering warfare agent sesquimustard with human serum albumin and its mass spectrometric identification for biomedical verification of exposure.
Blum MM, Richter A, Siegert M, Thiermann H, John H.
Anal. Bioanal. Chem. 2020; 412:7723-7737.
DOI: 10.1007/s00216-014-7706-yAdvice on chemical weapons sample stability and storage provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons to increase investigative capabilities worldwide.
Timperley CM, Forman JE, Abdollahi M, Al-Amri AS, Alonso IP, Baulig A, Borrett V, Cariño FA, Curty C, Berrutti DG, Kovarik Z, Martínez-Álvarez R, Mikulak R, Mourão NMF, Ponnadurai R, Neffe S, Raza SK, Rubaylo V, Takeuchi K, Tang C, Trifirò F, van Straten FM, Vanninen PS, Zaitsev V, Waqar F, Zina MS, Blum MM, Gregg H, Fischer E, Sun S, Yang P.
Talanta. 2018;188:808-832.
DOI: 10.1016/j.talanta.2018.04.022Sampling and analysis of organophosphorus nerve agents: analytical chemistry in international chemical disarmament.
Fischer E, Blum MM, Alwan WS, Forman JE.
Pure Appl. Chem. 2017; 89(2):249-258.
DOI: 10.1515/pac-2016-0902Analytical chemistry and the Chemical Weapons Convention.
Blum MM, Mamidanna RVSM.
Anal. Bioanal. Chem. 2014; 406(21):5067-5069.
DOI: 10.1007/s00216-014-7931-4V-type nerve agents phosphonylate ubiquitin at biologically relevant lysine residues and induce intramolecular cyclization by an isopeptide bond.
Schmidt C, Breyer F, Blum MM, Thiermann H, Worek F, John H.
Anal. Bioanal. Chem. 2014; 406(21):5171-5185.
DOI: 10.1007/s00216-014-7706-yAn enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: phase behavior, structure, and enzyme activity.
Stehle R, Schulreich C, Wellert S, Gäb J, Blum MM, Kehe K, Richardt A, Lapp A, Hellweg T.
J Colloid Interface Sci. 2014; 413:127-132.
DOI: 10.1016/j.jcis.2013.09.027Historical perspective and modern applications of Attenuated Total Reflectance –
Fourier Transform Infrared Spectroscopy (ATR-FTIR).
Blum MM, John H.
Drug Test. Anal. 2012; 4(3-4):292-308.
DOI: 10.1002/dta.374In vitro and in vivo efficacy of PEGylated Diisopropyl Fluorophosphatase (DFPase).
Melzer M, Heidenreich A, Dorandeu F, Gäb J, Kehe K, Thiermann H, Letzel T, Blum MM.
Drug Test. Anal. 2012; 4(3-4):262-270.
DOI: 10.1002/dta.363Review on UV-spectroscopic, chromatographic and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM).
John H, Blum MM.
Drug Test. Anal. 2012; 4(3-4):179-193.
DOI: 10.1002/dta.327The DFPase from Loligo Vulgaris in sugar surfactant based bicontinuous microemulsions.
Wellert S, Tiersch B, Koetz J, Richardt A, Lapp A, Holderer O, Gäb J, Blum MM, Schulreich C, Stehle R, Hellweg T.
Eur. Biophys. J. 2011; 40(6):761-774.
DOI: 10.1007/s00249-011-0689-0Formation of pyrophosphate-like adducts from nerve agents sarin, soman and cyclosarin in phosphate buffer:
Implications for analytical and toxicological investigations.
Gäb J, John H, Blum MM.
Toxicol. Lett. 2011; 200(1):34-40.
DOI: 10.1016/j.toxlet.2010.10.011Neutron structure and mechanistic studies of diisopropyl fluorophosphatase (DFPase).
Chen JC, Mustyakimov M, Schoenborn B, Langan P, Blum MM.
Acta Crystallogr. Sect. D Biol. Crystallogr. 2010; 66(11):1131-1138.
DOI: 10.1107/S0907444910034013Structural characterization of the catalytic calcium binding site in diisopropyl fluorophosphatase (DFPase) and comparison with related beta-propeller enzymes.
Blum MM, Chen JC.
Chem. Biol. Interact. 2010; 187(1-3):373-379.
DOI: 10.1016/j.cbi.2010.02.043X-ray structure of perdeuterated diisopropyl fluorophosphatase (DFPase):
Perdeuteration of proteins for neutron diffraction.
Blum MM, Tomanicek S, John H, Hanson L, Rüterjans H, Schoenborn BP, Langan P, Chen JC.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010; 66(4):379-385.
DOI: 10.1107/S1744309110004318Stable adducts of nerve agents sarin, soman and cyclosarin with TRIS, TES and related buffer compounds –
Characterization by LC-ESI-MS/MS and NMR and implications for analytical chemistry.
Gäb J, John H, Melzer M, Blum MM.
J. Chromatogr. B 2010; 878(17-18):1382-1390.
DOI': 10.1016/j.jchromb.2010.01.043Monitoring the hydrolysis of toxic organophosphonate nerve agents by diisopropyl fluorophosphatase (DFPase) in aqueous buffer and bicontinuous microemulsions with 1H-31P-HSQC NMR spectroscopy.
Gäb J, Melzer M, Kehe K, Wellert S, Hellweg T, Blum MM.
Anal. Bioanal. Chem. 2010;396(3):1213-1221.
DOI: 10.1007/s00216-009-3299-2Reversed Enantioselectivity of Diisopropyl Fluorophosphatase Against Organophohpsorus Nerve Agents by Rational Design.
Melzer M, Chen JC, Heidenreich A, Gäb J, Koller M, Kehe K, Blum MM.
J. Am. Chem. Soc. 2009;131(47):17226-17232.
DOI: 10.1021/ja905444gHighlighted in Nature Chemistry:
Nature Chem. 2010;2(1):4-5.
DOI: 10.1038/nchem.487Rapid determination of hydrogen positions and protonation states of diisopropyl fluorophosphatase by joint neutron and X-ray diffraction refinement.
Blum MM, Mustyakimov M, Rüterjans H, Kehe K, Schoenborn BP, Langan P, Chen JC.
Proc. Natl. Acad. Sci. U S A. 2009 Jan 20;106(3):713-8.
DOI: 10.1073/pnas.0807842106Quantification of hydrolysis of toxic organophosphates and organophosphonates by diisopropyl fluorophosphatase from Loligo vulgaris by in situ Fourier transform infrared spectroscopy.
Gäb J, Melzer M, Kehe K, Richardt A, Blum MM.
Anal. Biochem. 2009; 385(2):187-193.
DOI: 10.1016/j.ab.2008.11.012Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.
Blum MM, Timperley CM, Williams GR, Thiermann H, Worek F.
Biochemistry 2008; 47(18):5216-24.
DOI: 10.1021/bi702222xPreliminary time-of-flight neutron diffraction study on diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris.
Blum MM, Koglin A, Rüterjans H, Schoenborn B, Langan P, Chen JC.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2007; 63(1):42-5.
DOI: 10.1107/S1744309106052924Binding of a designed substrate analogue to diisopropyl fluorophosphatase: implications for the phosphotriesterase mechanism.
Blum MM, Löhr F, Richardt A, Rüterjans H, Chen JC.
J. Am. Chem. Soc. 2006; 128(39):12750-7.
DOI: 10.1021/ja061887nWas wissen Calamari über Sarin? Enzymatische Dekontamination von Nervenkampfstoffen
Richardt A, Blum MM, Mitchell S.
Chemie in unserer Zeit. 2006; 40(4):252-259.
DOI: 10.1002/ciuz.200600364Conformational switches modulate protein interactions in peptide antibiotic synthetases.
Koglin A, Mofid MR, Löhr F, Schäfer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dötsch V.
Science. 2006; 312(5771):273-6.
DOI: 10.1126/science.1122928